From New York & New Jersey via I-80
(see map below)
(Official Map Questing Address below)

Here is an easy set of directions from NY and NJ once you are on Rt. 80 West...

All one has to do to get to the POCONO BREWING COMPANY is make your way onto 80 West...  either from the GWB or the Lincoln Tunnel.  Once you get to 80 west, you go
through New Jersey and you'll end up at the Delaware Water Gap Toll Bridge. 
( From NYC you are about 55 miles or so on 80 west)

  *80 West will take you to the Delaware Water Gap Toll Plaza. (This is where NJ ends and Pennsylvania begins.) 

 Stay straight on 80 west after the DWG toll plaza. From the DWG toll plaza, you'll pass many exits. (Marshall's Creek, East Stroudsburg,  Bartonsville and Tannersville) before you get to the "Scotrun" exit 298 (old exit 44), which is about 10 miles from the DWG toll plaza.
Scotrun exits to the right. Make the left at the bottom of the ramp onto Rt. 611(very easy and no confusion)
 
This route is the road PBC is on(Rt. 611) It's on your left hand side about 2-3 miles once you make the left. 
You'll see the Pocono Brewing Company and a big sign lit up. You cannot miss it. Stay on Rt. 611 South.  From NYC with no traffic it's about 1 hour and 20 minutes.
*SEE MAP BELOW

The official address for Map Quest is:
C 1 Box 88  Route 611   Swiftwater  PA  18370